Granneman Lab

The role of non-coding RNAs and RNA-binding proteins in regulating rapid adaptive responses in microbes

We study post-transcriptional regulation mechanisms in budding yeast and methicillin-resistant Staphylococcus aureus, focussing on the role of non-coding RNAs and RNA-binding proteins and how they regulate adaptation to the host.
To tackle these research questions, we developed and employed high-throughput systems biology approaches for monitoring protein-RNA (CRAC), RNA-RNA (CLASH) and RNA structure (ChemModSeq) in living cells.

To extract all the relevant information from these high-throughput datasets, we have developed bespoke Software pipelines and tools. Moreover, for our protein-RNA interactome studies, we have collaborated for many years with UVO3 to develop much improved UV irradiation Hardware.

Our Research